Diagnostic biomarker reagents for medical purposes; biomarkers for use individually or in combination to detect tissue formation, tissue remodeling, or tissue destruction; diagnostic biomarker assays to identify disease activity for medical use; diagnostic biomarker assays for medical use to quantify disease activity; diagnostic biomarker assays for medical use to analyse disease activity; diagnostic kits comprised of medical diagnostic reagents and assays for testing bodily fluids for use in...