A chemical formulation comprising hydroxychloroquine for use in targeting malignant cells by inhibiting drug resistance, improving chemotherapy cell penetration, potentiation of presentation of major histocompatibility complexes, intercalating directly into DNA; a chemical formulation comprising hydroxychloroquine for use in tempering severe systemic inflammatory responses to filoviruses through dysregulation of lysosomes and lysosomal pH through decreased production of tumor necrosis factor ...