Pharmaceutical agents affecting DNA structure by targeting DNA structure to treat various diseases in the nature of monogenic diseases, cancer, infectious disease, immune disease, hematological conditions, haploinsufficiencies, hepatic disease, channelopathies, endocrine disease, cardiovascular disease, reproductive disease, renal disease, skeletal muscle disease, bone disease, multigenic disorders, hepatic disorders and disorders of the CNS, none of the foregoing including omega fatty acids