Pharmaceutical preparations, namely, oligonucleotides, siRNA and antisense RNA for use in the treatment of cancer, hepatitis, neurodegenerative diseases, neurological diseases, hemophilia, complement-mediated disease, hypercholesterolemia, rare genetic diseases, cardio-metabolic diseases, hepatic infectious diseases, rare bleeding disorders, iron overload disorders, hypertriglyceridemia, mixed hyperlipidemia, hypertriglyceridemia, hypertension, preeclampsia, chronic liver infection, anemia, m...