Transdermal patches for delivering bioactive agents for use in the treatment of internal, medical, endocrine, pulmonary, cardiological, hematological, chronic pain, gastronenterolgical, rheumatological, neurological, nephrological, orthopedic, pediatric, psychological, obstetrical, gynecological, pre-operative, surgical, post-operative, vascular and urological conditions through enhanced permeability of the skin