Pharmaceutical preparations, namely, drug preparations comprising small particles for enhanced absorption and therapeutic effect for the treatment of cancer, including pancreatic cancer, melanoma, skin cancer, lung cancer, breast cancer, prostate cancer, colorectal cancer, kidney cancer, stomach cancer, ovarian cancer, cervical cancer, liver cancer, multiple myeloma, lymphoma, glioma, glioblastoma, diffuse midline glioma, brain or spinal cancer, CNS tumors, HIV-AIDS, myelodysplastic disease, ...